Carbazochrome sodium sulfonate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Carbazochrome sodium sulfonate (AC-17) 是一种毛细管稳定剂，用于出血的研究。Carbazochrome sodium sulfonate 是一种抗出血剂。

Carbazochrome sodium sulfonate (AC-17) is an antihemorrhagic for use in the treatment of hemorrhoids(In Vitro):Carbazochrome (0.1-10 μM) inhibits the Bradykinin induced and thrombin-induced formation of [3H]IP3 in a concentration-dependent manner. Carbazochrome (0.1-1 μM), when included from 30 min before stimulation, significantly suppressed the enhancement of permeability induced by vasoactive substances.(In Vivo):Carbazochrome inhibits the severe pulmonary dysfunction induced by the intravenous injection of radiographic contrast media. Carbazochrome (1-10 mg/kg, i.v.) attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats.

Carbazochrome (0.1-10 μM) inhibits the Bradykinin induced and thrombin-induced formation of [3H]IP3in a concentration-dependent manner.Carbazochrome (0.1-1 μM), when included from 30 min before stimulation, significantly suppressed the enhancement of permeability induced by vasoactive substances.

Carbazochrome inhibits the severe pulmonary dysfunction induced by the intravenous injection of radiographic contrast media. Carbazochrome (1-10 mg/kg, i.v.) attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats. Animal Model:Male Sprague-Dawley rats weighing 180-230 g Dosage:1, 5 and 10 mg/kg Administration:I.v.; injected 30, 60, or 90 min before Ioxaglate injection (4 g I/kg, i.v.).Result:Attenuated the Ioxaglate-increased vascular permeability at the dose of 1, 5 and 10 mg/kg in a dose-dependent manner, achieving statistical significance at 5 and 10 mg/kg.

AC17 | 4arylidene curcumin |

Others

Other Targets

Others

Cardiovascular Disease

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51460-26-5

376.32

C10H17N4NaO8S

>98% (HPLC)

Water: 3 mg/mL (9.3 mM); DMSO: 64 mg/mL (198.59 mM)

O=C(/C(C(/C=C/C1=CC=C(OC)C(OC)=C1)=O)=C/C2=CC=C(O)C(OC)=C2)/C=C/C3=CC=C(OC)C(OC)=C3

(1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4-(4-hydroxy-3-methoxybenzylidene)hepta-1,6-diene-3,5-dione

(-20℃)

With Ice Pack

≥ 2 years